Search results for " Indian"
showing 10 items of 57 documents
A sea surface temperature reconstruction for the southern Indian Ocean trade wind belt from corals in Rodrigues Island (19°S, 63°E)
2016
Abstract. The western Indian Ocean has been warming rapidly over recent decades, causing a greater number of extreme climatic events. It is therefore of paramount importance to improve our understanding of links between Indian Ocean sea surface temperature (SST) variability, climate change and sustainability of tropical coral reef ecosystems. Here we present monthly resolved coral Sr ∕ Ca records from two different locations from Rodrigues Island (63° E, 19° S) in the south-central Indian Ocean trade wind belt. We reconstruct SST based on a linear relationship with the Sr ∕ Ca proxy with records starting from 1781 and 1945, respectively. We assess relationships between the observed long-ter…
Selection for Robustness in Mutagenized RNA Viruses
2007
Mutational robustness is defined as the constancy of a phenotype in the face of deleterious mutations. Whether robustness can be directly favored by natural selection remains controversial. Theory and in silico experiments predict that, at high mutation rates, slow-replicating genotypes can potentially outcompete faster counterparts if they benefit from a higher robustness. Here, we experimentally validate this hypothesis, dubbed the ‘‘survival of the flattest,’’ using two populations of the vesicular stomatitis RNA virus. Characterization of fitness distributions and genetic variability indicated that one population showed a higher replication rate, whereas the other was more robust to mut…
Improved display of synthetic IgG-binding domains on the baculovirus surface.
2004
Improved display of foreign protein moieties in combination with beneficial alteration of the viral surface properties should be of value for targeted and enhanced gene delivery. Here, we describe a vector based on Autographa californica multiple nucleopolyhedrovirus (AcMNPV) displaying synthetic IgG-binding domains (ZZ) of protein A fused to the transmembrane anchor of vesicular stomatitis virus (VSV) G protein. This display vector was equipped with a GFP/EGFP expression cassette enabling fluorescent detection in both insect and mammalian cells. The virus construct displayed the biologically active fusion protein efficiently and showed increased binding capacity to IgG. As the display is …
Fibrinogen Gamma Chain Promotes Aggregation of Vesicular Stomatitis Virus in Saliva.
2020
This article belongs to the Section Animal Viruses.
Effect of a Brassica Juncea Cover Crop on a Mono-Succession of Melon
2013
The ban of methyl bromide and the need for low environmental impact of agriculture has recently increased the interest in the biofumigant effects of Brassica species on soil-borne pathogens. Many researches have tested the toxic effects of Brassica green manures on several soil-borne pathogens in vitro, but field studies have not assessed definitely the efficiency of biofumigation at the field scale and the effect on crop development and production quality. The aim of this research was to evaluate the effect of a winter-spring cover crop of Brassica juncea compared to bare soil on a mono-succession of melon. The biomass of the B. juncea plants or of the weeds eventually developed in bare so…
Modification of the southern African rainfall variability/ENSO relationship since the late 1960s
2000
Analysis of 149 raingauge series (1946–1988) shows a weak positive correlation between late summer rainfalls (January–March) in tropical southern Africa and the Southern Oscillation Index (SOI). The correlation coefficients have been unstable since World War II. They were close to zero before 1970 and significant thereafter. Before 1970, southern African late summer rainfalls were more specifically correlated with regional patterns of sea surface temperature (SST), mainly over the southwestern Indian Ocean. After 1970, teleconnections with near global SST anomaly patterns, i.e. over the central Pacific and Indian oceans, dominate the regional connections. The increase in the sensitivity of …
T-cell receptor transfer into human T cells with ecotropic retroviral vectors
2014
Adoptive T-cell transfer for cancer immunotherapy requires genetic modification of T cells with recombinant T-cell receptors (TCRs). Amphotropic retroviral vectors (RVs) used for TCR transduction for this purpose are considered safe in principle. Despite this, TCR-coding and packaging vectors could theoretically recombine to produce replication competent vectors (RCVs), and transduced T-cell preparations must be proven free of RCV. To eliminate the need for RCV testing, we transduced human T cells with ecotropic RVs so potential RCV would be non-infectious for human cells. We show that transfection of synthetic messenger RNA encoding murine cationic amino-acid transporter 1 (mCAT-1), the re…
Are the new genetic tools for diagnosis of Wilson disease helpful in clinical practice?
2020
Summary The diagnosis of Wilson disease is not always easy. For many patients, a combination of tests reflecting disturbed copper metabolism may be needed. Testing for ATP7B variants has become part of the routine diagnostic approach. The methods of genetic testing include analysis of the 21 coding exons and intronic flanking sequences, in which exons with recurrent variants would be prioritised depending on the mutation frequency in the local population. If sequencing the entire ATP7B gene cannot identify 2 variants and the suspicion for Wilson disease is high, after reviewing the clinical data, WES (whole-exome sequencing) or WGS (whole-genome sequencing) could be applied. A workflow base…
Gli Studi Culturali in India. Il collettivo Subaltern Studies e il discorso postcoloniale da Said a Spivak
2012
Sull'origine e lo sviluppo del collettivo "Subaltern Studies" in India, sul ruolo fondamentale che ha giocato nella formazione degli Studi Culturali e Postcoloniali, e sulla sua diffusione transnazionale.
“Things which don’t shift and grow are dead things”: Revisiting Betonie’s Waste-Lands in Leslie Silko’s Ceremony
2014
This article explores the socio-political background that led to widespread Native American urban relocation in the period following World War II – a historical episode which is featured in Leslie Marmon Silko’s acclaimed novel Ceremony (1977). Through an analysis of the recycling, reinterpreting practices carried out by one of Ceremony’s memorable supporting characters, Navajo healer Betonie, Silko’s political aim to interrogate the state of things and to re-value Native traditions in a context of ongoing relations of coloniality is made most clear. In Silko’s novel, Betonie acts as an organic intellectual who is able to identify and challenge the 1950s neocolonial structure that forced Na…